Pharmacokinetics of Vindesine and Vincristine in Humans 1
نویسنده
چکیده
ti,2f3= 99.0 ± 44.5 mm, t112y = 1213 ± 493 mm, V@ (Va) 4.81 ±2.l2lihens, V@= 58.2 ±50.Slihens,V7 = 598 ±294 liters. Vincnishine, studied only for hhe finsh 4 hn, behaved like a Iwo-compartment system, wihh values of t,,2 a 3.37 ±0.72 min,t,,2 /3 = 155 ±18 mm, v@= 4.53 ±0.49 liters, and V@ = 57.3 ± 21.1 liters. Urine excretiondaha demonstrahed that most drug elimination occurred wihhin the first 24 hr and amounhed ho 13.2 ±5.9% for vindesine and 9.5 ±5.1% for vincnishine.
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